I do a combination of packing. I LOVE large zip-lock bags, and pack-it cubes.

I fold pants in half, half again (fits perfectly in half suitcase), or sometimes just in half.

Underwear goes in pack-it cubes
toiletries in zip-lock bags
(and the zip-locks make great dirty laundry bags coming home.

I usually lay everything out on the bed according to "type". Bathing, daytime t-shirts etc.....I will usually try to put each stack straight in the suitcase (I use "department store folding" for most shirts). I sometimes roll t-shirts.

I actually dont mind ironing. What I will do is when I unpack I will take 20 min and iron whatever needs it for the first couple of days. Otherwise the wrinkles usually hang out.

And of course, I take too much. I actually do TWO suitcases, so I know in Sept I will pay $20 for the second suitcase on jet blue but its cheaper than paying overweight of $50.